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KMID : 1149220160240040271
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Korean Journal of Oriental Medical Prescription
2016 Volume.24 No. 4 p.271 ~ p.282
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Comparison of Four Multi-herbal Formulas in Antioxidant and Anticancer Activities
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Kim Hong-Jae
Choi Eun-Ok
Kim Min-Young
Son Da-Hee
Jeong Jin-Woo
Lee Sang-Hyup
Park Cheol
Choi Yung-Hyun
Hong Su-Hyun
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Abstract
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Objective : In this study, we compared the antioxidant and anticancer properties of four multi-herbal formulas which were recorded in 'Dongeuibogam': Gilgyung-tang (GGT), Mokdanpi-tang (MDPT), Samso-eum (SSE), Samchulbobi-tang (SCBBT).
Methods : We checked antioxidant properties of four multi-herbal formula through total phenolic content, radical scavenging activities, protective effects on genomic DNA oxidation. To investigate anticancer effects, we conducted MTT assay and analyzed morphologic change in A549 non-small lung cancer cells.
Results : Total phenolic contents of four multi-herbal formulas were in a rich order of MDPT > SSE > GGT > SCBBT. Especially, MDPT revealed the highest activity than others in all antioxidant experiments. Our results indicated that treatment of those multi-herbal formulas induced growth retardation in A549 cells and MDPT also showed the highest anticancer effect (IC50=1.374mg/ml) among them.
Conclusions : Our data suggested that MDPT would be a powerful ingredient for lung cancer treatment.
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KEYWORD
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Antioxidant activity , anticancer activity , multi-herbal formula , Mokdanpi-tang
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